Research & Development

End-to-End solutions

Between practice and theory, we have extensive experience, broad scientific expertise, and connections, as well as a selected, interdisciplinary team of specialists at our disposal. With them, we follow a structured path to gain new insights in various development processes. To implement this, we utilize a wide range of modern manufacturing and analytical methods.

Additive Manufacturing

Additive Manufacturing, commonly known as 3D printing, has revolutionized the production of complex geometries with various materials. One of our focal points lies in the development of additive manufacturing of bioabsorbable magnesium and zinc alloys. The unique challenges posed by factors such as the reactivity and flammability of magnesium have prompted us to seek innovative approaches for its successful integration into AM processes.

Additionally, we are engaged in post-processing of additively manufactured components. Methods for surface treatment are developed to meet the challenges and requirements of this technology area.

Surface technologies

Plasma-elektrolytic Oxidation

Plasma Electrolytic Oxidation (PEO) is an advanced surface modification process that enhances the properties of metals and alloys. By applying an electric potential to a component immersed in an electrolyte solution, a plasma discharge triggers electrochemical reactions, leading to the formation of a ceramic-like oxide layer. This layer can be individually tailored to your application in terms of thickness, composition, and structure, resulting, for instance, in improved corrosion resistance, wear resistance, hardness, and other desirable properties. The unique microstructure of PEO, including nanopores and crystalline phases, further contributes to its effectiveness. The PEO technology employed by Meotec is applied in various fields: medical technology, aerospace, propulsion technology, renewable energy systems, and is subject to continuous research and innovation.

Electropolishing

Electrochemical etching is a controlled and precise surface modification technique, where material is selectively removed from a metal substrate through electrochemical reactions. In this process, the metal is immersed in an electrolyte solution, and a direct current (DC) or alternating current (AC) is applied. This causes metal ions to be dissolved from the surface, enabling effortless processing of complex geometries.

Our technology is applied across various industries, particularly in the manufacturing of medical implants, the automotive industry, and the aerospace sector. It is also utilized for post-processing of additively manufactured parts.

Both technologies are integral components of our Engineered Systems portfolio and are accommodated within our automated manufacturing facilities

Analytics

Our in-house analytics encompass all metallographic, chemical, optical, and mechanical characterization capabilities necessary to fully and independently handle development processes. With a wide range of analytical equipment and the expertise of experienced staff, we can respond promptly to individual customer or project requirements.

Collaborative Research

The combination of versatile manufacturing processes, process chains for the production of medically suitable materials or entire implant systems, and in-house analytics makes us an outstanding partner in the field of contract research.

R&D Cooperations

The foundation of our company is science. Without thorough knowledge and testing, no product can reach market readiness.

Our partnership with RWTH Aachen University and FH Aachen University is reflected in numerous R&D cooperation projects. We have published our current projects under ‘News’.

Publications

As one of the leading providers of bioabsorbable metals, Meotec GmbH has many years of experience in the development and series production of magnesium-based implant systems. Our expertise is built on state-of-the-art manufacturing technologies and a strong scientific focus.

In cooperation with local, national, and international research institutions and universities, we continuously work on pioneering innovations. Our key areas of focus include:

  • Novel manufacturing and processing technologies

  • Innovative surface coating solutions

  • Expansion of standardized testing and validation methods

  • Material and process simulations

  • Translation of new materials and processes into clinical applications

Together with our partners, we regularly publish scientific work in renowned journals and peer-reviewed publications.

Below you will find an overview of our publications on materials, manufacturing processes, and preclinical as well as clinical studies on bioabsorbable implants:

Year Authors Title Journal DOI
2026 Martin-Alonso, M.D.; Dominguez, G.; Benn, F.; Pöstges, S.; Kopp, A.; Villanova, J.; Lhuissier, P.; Molina-Aldareguia, J.; Sket, F. In situ multiscale XCT degradation study of PEO-modified WE43 scaffolds: Correlating microstructure with hydrogen evolution Additive Manufacturing 10.1016/j.addma.2025.105042
2025 Domínguez, Guillermo; Li, Muzi; Pöstges, Simon; Kopp, Alexander; Serdechnova, Maria; Blawert, Carsten; LLorca, Javier; Patterson, Jennifer; Echeverry, Mónica; Molina-Aldareguia, Jon Influence of manufacturing route and surface modification on the corrosion behavior of WE43 Mg and Zn1Mg bioabsorbable metallic alloys Surface and Coatings Technology 10.1016/j.surfcoat.2025.132461
2024 Zhang, Dawei; Ma, Songyun; Nachtsheim, Julia; Zhang, Shunqi; Markert, Bernd A variational phase-field framework for multiphysics modelling of degradation and stress corrosion cracking in biodegradable magnesium alloys Journal of the Mechanics and Physics of Solids 10.1016/j.jmps.2024.105694
2024 Turostowski, Marta; Rendenbach, Carsten; Herzog, Paulina; Ellinghaus, Agnes; Prates Soares, Ana; Heiland, Max; Duda, Georg N.; Schmidt-Bleek, Katharina; Fischer, Heilwig Titanium vs PEO Surface-Modified Magnesium Plate Fixation in a Mandible Bone Healing Model in Sheep ACS Biomaterials Science & Engineering 10.1021/acsbiomaterials.4c00602
2024 Thompson, Cillian; Domínguez, Guillermo; Bardisa, Pilar; Liu, Yuyao; Fernández‐Blázquez, Juan Pedro; Del Río, José Sánchez; Echeverry‐Rendon, Monica; González, Carlos; Llorca, Javier Medical grade 3D printable bioabsorbable PLDL/Mg and PLDL/Zn composites for biomedical applications Journal of Biomedical Materials Research Part A 10.1002/jbm.a.37660
2024 Nachtsheim, Julia; Ma, Songyun; Burja, Jaka; Markert, Bernd In vitro evaluation of stress corrosion cracking susceptibility of PEO-coated rare-earth magnesium alloy WE43 Surface and Coatings Technology 10.1016/j.surfcoat.2024.130391
2024 Nachtsheim, Julia; Ma, Songyun; Burja, Jaka; Kopp, Alexander; Seitz, Jan-Marten; Markert, Bernd In vitro corrosion-fatigue behaviour of rare-earth containing magnesium WE43 in sterile complex cell culture medium International Journal of Fatigue 10.1016/j.ijfatigue.2024.108531
2024 Herzog, Paulina; Rendenbach, Carsten; Turostowski, Marta; Ellinghaus, Agnes; Prates Soares, Ana; Heiland, Max; Duda, Georg N.; Schmidt-Bleek, Katharina; Fischer, Heilwig Titanium versus plasma electrolytic oxidation surface-modified magnesium miniplates in a forehead secondary fracture healing model in sheep Acta Biomaterialia 10.1016/j.actbio.2024.07.005
2024 Ali, Wahaaj; González, Carlos; Kopp, Alexander; LLorca, Javier Bioabsorbable Composite Laminates of Poly‐Lactic Acid Reinforced with Surface‐Modified Mg Wires for Orthopedic Implant Applications Advanced Engineering Materials 10.1002/adem.202400617
2023 Kopp, Alexander; Fischer, Heilwig; Soares, Ana Prates; Schmidt-Bleek, Katharina; Leber, Christoph; Kreiker, Henri; Duda, Georg; Kröger, Nadja; Van Gaalen, Kerstin; Hanken, Henning; Jung, Ole; Smeets, Ralf; Heiland, Max; Rendenbach, Carsten Long-term in vivo observations show biocompatibility and performance of ZX00 magnesium screws surface-modified by plasma-electrolytic oxidation in Göttingen miniature pigs Acta Biomaterialia 10.1016/j.actbio.2022.11.052
2023 Ali, Wahaaj; Echeverry-Rendón, Mónica; Dominguez, Guillermo; Van Gaalen, Kerstin; Kopp, Alexander; González, Carlos; LLorca, Javier Bioabsorbable WE43 Mg alloy wires modified by continuous plasma electrolytic oxidation for implant applications. Part II: Degradation and biological performance Biomaterials Advances 10.1016/j.bioadv.2023.213325
2023 Ali, Wahaaj; Echeverry-Rendón, Mónica; Kopp, Alexander; González, Carlos; LLorca, Javier Effect of surface modification on interfacial behavior in bioabsorbable magnesium wire reinforced poly-lactic acid polymer composites npj Materials Degradation 10.1038/s41529-023-00386-x
2023 Ali, Wahaaj; Li, Muzi; Tillmann, Leon; Mayer, Tim; González, Carlos; LLorca, Javier; Kopp, Alexander Bioabsorbable WE43 Mg alloy wires modified by continuous plasma-electrolytic oxidation for implant applications. Part I: Processing, microstructure and mechanical properties Biomaterials Advances 10.1016/j.bioadv.2023.213314
2023 Fuest, Sandra; Smeets, Ralf; Gosau, Martin; Aavani, Farzaneh; Knipfer, Christian; Grust, Audrey Laure Céline; Kopp, Alexander; Becerikli, Mustafa; Behr, Björn; Matthies, Levi Layer-by-Layer Deposition of Regenerated Silk Fibroin─An Approach to the Surface Coating of Biomedical Implant Materials ACS Biomaterials Science & Engineering 10.1021/acsbiomaterials.3c00852
2023 Zhou, Juncen; Georgas, Elias; Su, Yingchao; Zhou, Jiayi; Kröger, Nadja; Benn, Felix; Kopp, Alexander; Qin, Yi‐Xian; Zhu, Donghui Evolution from Bioinert to Bioresorbable: In Vivo Comparative Study of Additively Manufactured Metal Bone Scaffolds Advanced Science 10.1002/advs.202302702
2023 Quinn, Conall; Van Gaalen, Kerstin; McHugh, Peter E.; Kopp, Alexander; Vaughan, Ted J. An enhanced phenomenological model to predict surface-based localised corrosion of magnesium alloys for medical use Journal of the Mechanical Behavior of Biomedical Materials 10.1016/j.jmbbm.2022.105637
2023 Van Gaalen, Kerstin; Quinn, Conall; Benn, Felix; McHugh, Peter E.; Kopp, Alexander; Vaughan, Ted J. Linking the effect of localised pitting corrosion with mechanical integrity of a rare earth magnesium alloy for implant use Bioactive Materials 10.1016/j.bioactmat.2022.08.004
2023 Van Gaalen, Kerstin; Quinn, Conall; Weiler, Marek; Gremse, Felix; Benn, Felix; McHugh, Peter E.; Vaughan, Ted J.; Kopp, Alexander Predicting localised corrosion and mechanical performance of a PEO surface modified rare earth magnesium alloy for implant use through in-silico modelling Bioactive Materials 10.1016/j.bioactmat.2023.03.009
2022 Van Gaalen, Kerstin; Gremse, Felix; Benn, Felix; McHugh, Peter E.; Kopp, Alexander; Vaughan, Ted J. Automated ex-situ detection of pitting corrosion and its effect on the mechanical integrity of rare earth magnesium alloy - WE43 Bioactive Materials 10.1016/j.bioactmat.2021.06.024
2022 Zeng, Zhuoran; Choudhary, Sanjay; Esmaily, Marco; Benn, Felix; Derra, Thomas; Hora, Yvonne; Kopp, Alexander; Allanore, Antoine; Birbilis, Nick An additively manufactured magnesium-aluminium alloy withstands seawater corrosion npj Materials Degradation 10.1038/s41529-022-00241-5
2022 Saconi, Felipe; Diaz, Geraldine Hincapie; Vieira, André Costa; Ribeiro, Marcelo Leite Experimental Characterization and Numerical Modeling of the Corrosion Effect on the Mechanical Properties of the Biodegradable Magnesium Alloy WE43 for Orthopedic Applications Materials 10.3390/ma15207164
2022 Kozakiewicz, Marcin; Gabryelczak, Izabela; Bielecki-Kowalski, Bartosz Clinical Evaluation of Magnesium Alloy Osteosynthesis in the Mandibular Head Materials 10.3390/ma15030711
2022 González-Pérez, Fernando; Acosta, Sergio; Rütten, Stephan; Emonts, Caroline; Kopp, Alexander; Henke, Heinz-Werner; Bruners, Philipp; Gries, Thomas; Rodríguez-Cabello, J. Carlos; Jockenhoevel, Stefan; Fernández-Colino, Alicia Biohybrid elastin-like venous valve with potential for in situ tissue engineering Frontiers in Bioengineering and Biotechnology 10.3389/fbioe.2022.988533
2022 Fischer, Heilwig; Schmidt-Bleek, Oskar; Orassi, Vincenzo; Wulsten, Dag; Schmidt-Bleek, Katharina; Heiland, Max; Steffen, Claudius; Rendenbach, Carsten Biomechanical Comparison of WE43-Based Magnesium vs. Titanium Miniplates in a Mandible Fracture Model in Sheep Materials 10.3390/ma16010102
2021 Ali, Wahaaj; Echeverry-Rendón, Mónica; Kopp, Alexander; González, Carlos; LLorca, Javier Strength, corrosion resistance and cellular response of interfaces in bioresorbable poly-lactic acid/Mg fiber composites for orthopedic applications Journal of the Mechanical Behavior of Biomedical Materials 10.1016/j.jmbbm.2021.104781
2021 Rendenbach, Carsten; Fischer, Heilwig; Kopp, Alexander; Schmidt-Bleek, Katharina; Kreiker, Henri; Stumpp, Sabine; Thiele, Mario; Duda, Georg; Hanken, Henning; Beck-Broichsitter, Benedicta; Jung, Ole; Kröger, Nadja; Smeets, Ralf; Heiland, Max Improved in vivo osseointegration and degradation behavior of PEO surface-modified WE43 magnesium plates and screws after 6 and 12 months Materials Science and Engineering: C 10.1016/j.msec.2021.112380
2021 Li, Muzi; Benn, Felix; Derra, Thomas; Kröger, Nadja; Zinser, Max; Smeets, Ralf; Molina-Aldareguia, Jon M.; Kopp, Alexander; LLorca, Javier Microstructure, mechanical properties, corrosion resistance and cytocompatibility of WE43 Mg alloy scaffolds fabricated by laser powder bed fusion for biomedical applications Materials Science and Engineering: C 10.1016/j.msec.2020.111623
2021 Kozakiewicz, Marcin Change in Pull-Out Force during Resorption of Magnesium Compression Screws for Osteosynthesis of Mandibular Condylar Fractures Materials https://doi.org/10.3390/ma14020237
2021 Benn, Felix; Kröger, Nadja; Zinser, Max; Van Gaalen, Kerstin; Vaughan, Ted J.; Yan, Ming; Smeets, Ralf; Bibiza, Eric; Malinov, Savko; Buchanan, Fraser; Kopp, Alexander Influence of surface condition on the degradation behaviour and biocompatibility of additively manufactured WE43 Materials Science and Engineering: C 10.1016/j.msec.2021.112016
2020 Esmaily, M.; Zeng, Z.; Mortazavi, A.N.; Gullino, A.; Choudhary, S.; Derra, T.; Benn, F.; D'Elia, F.; Müther, M.; Thomas, S.; Huang, A.; Allanore, A.; Kopp, A.; Birbilis, N. A detailed microstructural and corrosion analysis of magnesium alloy WE43 manufactured by selective laser melting Additive Manufacturing 10.1016/j.addma.2020.101321
2020 Kozakiewicz, Marcin Are Magnesium Screws Proper for Mandibular Condyle Head Osteosynthesis? Materials 10.3390/ma13112641
2019 Kopp, Alexander; Smeets, Ralf; Jung, Ole; Kröger, Nadja; Klink, Andreas Defined surface adjustment for medical magnesium implants by electrical discharge machining (EDM) and plasma electrolytic oxidation (PEO) CIRP Annals 10.1016/j.cirp.2019.04.016
2019 Kopp, Alexander; Derra, Thomas; Müther, Max; Jauer, Lucas; Schleifenbaum, Johannes H.; Voshage, Maximilian; Jung, Ole; Smeets, Ralf; Kröger, Nadja Influence of design and postprocessing parameters on the degradation behavior and mechanical properties of additively manufactured magnesium scaffolds Acta Biomaterialia 10.1016/j.actbio.2019.04.012
2019 Jung, Ole; Smeets, Ralf; Hartjen, Philip; Schnettler, Reinhard; Feyerabend, Frank; Klein, Martin; Wegner, Nils; Walther, Frank; Stangier, Dominic; Henningsen, Anders; Rendenbach, Carsten; Heiland, Max; Barbeck, Mike; Kopp, Alexander Improved In Vitro Test Procedure for Full Assessment of the Cytocompatibility of Degradable Magnesium Based on ISO 10993-5/-12 International Journal of Molecular Sciences 10.3390/ijms20020255
2019 Jung, Ole; Porchetta, Dario; Schroeder, Marie-Luise; Klein, Martin; Wegner, Nils; Walther, Frank; Feyerabend, Frank; Barbeck, Mike; Kopp, Alexander In Vivo Simulation of Magnesium Degradability Using a New Fluid Dynamic Bench Testing Approach International Journal of Molecular Sciences 10.3390/ijms20194859
2019 D’Elia, Francesco; Hiester, Philipp; Zimmermann, Carlo; Schestakow, Igor; Horky, Jelena; Krystian, Maciej; Kopp, Alexander Influence of Equal Channel Angular Processing and Rotary Swaging on the Mechanical and Degradation Properties of WE43 Mg Alloy SSRN Electronic Journal 10.2139/ssrn.3313274
2018 Kröger, Nadja; Kopp, Alexander; Staudt, Mareike; Rusu, Mihaela; Schuh, Alexander; Liehn, Elisa A. Hemocompatibility of plasma electrolytic oxidation (PEO) coated Mg-RE and Mg-Zn-Ca alloys for vascular scaffold applications Materials Science and Engineering: C 10.1016/j.msec.2018.07.031
2015 Jung, Ole; Smeets, Ralf; Porchetta, Dario; Kopp, Alexander; Ptock, Christoph; Müller, Ute; Heiland, Max; Schwade, Max; Behr, Björn; Kröger, Nadja; Kluwe, Lan; Hanken, Henning; Hartjen, Philip Optimized in vitro procedure for assessing the cytocompatibility of magnesium-based biomaterials Acta Biomaterialia 10.1016/j.actbio.2015.06.005
2013 Klocke, F.; Schwade, M.; Klink, A.; Veselovac, D.; Kopp, A. Influence of Electro Discharge Machining of Biodegradable Magnesium on the Biocompatibility Procedia CIRP 10.1016/j.procir.2013.01.018
2011 Klocke, F.; Schwade, M.; Klink, A.; Kopp, A. EDM Machining Capabilities of Magnesium (Mg) Alloy WE43 for Medical Applications Procedia Engineering 10.1016/j.proeng.2011.11.100